Opioid Agonist [EPC] — Common Side Effects
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| Side Effect | Total Reports | Drugs | Deaths | Hosp. | Life-Threat. |
|---|---|---|---|---|---|
| Drug dependence | 240,439 | 14 | 29,872 | 15,035 | 977 |
| Overdose | 162,913 | 15 | 68,972 | 12,481 | 2,622 |
| Pain | 129,293 | 15 | 6,530 | 11,881 | 3,387 |
| Death | 119,098 | 15 | 118,969 | 4,231 | 344 |
| Emotional distress | 103,946 | 13 | 2,467 | 2,040 | 195 |
| Toxicity to various agents | 102,813 | 15 | 84,674 | 18,370 | 2,489 |
| Drug withdrawal syndrome | 83,147 | 13 | 3,931 | 4,535 | 532 |
| Drug abuse | 53,714 | 14 | 34,037 | 10,097 | 1,448 |
| Drug ineffective | 36,231 | 15 | 3,464 | 9,359 | 3,173 |
| Drug hypersensitivity | 35,061 | 14 | 2,768 | 4,552 | 2,354 |
| Dependence | 33,995 | 12 | 3,838 | 631 | 87 |
| Nausea | 23,416 | 15 | 3,875 | 8,852 | 2,730 |
| Drug withdrawal syndrome neonatal | 22,619 | 12 | 375 | 2,831 | 60 |
| Anxiety | 21,864 | 14 | 2,488 | 4,799 | 1,568 |
| Vomiting | 20,020 | 15 | 4,687 | 8,403 | 3,419 |
| Depression | 19,796 | 12 | 3,710 | 4,978 | 1,989 |
| Foetal exposure during pregnancy | 18,581 | 15 | 559 | 3,228 | 165 |
| Off label use | 17,883 | 14 | 4,629 | 7,870 | 4,018 |
| Fatigue | 15,993 | 12 | 4,179 | 6,824 | 3,083 |
| Headache | 15,652 | 15 | 3,550 | 6,231 | 2,573 |
| Dyspnoea | 13,747 | 15 | 3,529 | 6,011 | 2,598 |
| Constipation | 13,727 | 14 | 1,779 | 5,318 | 547 |
| Completed suicide | 13,227 | 13 | 13,146 | 2,456 | 183 |
| Somnolence | 13,069 | 14 | 2,060 | 5,492 | 1,094 |
| Rash | 12,486 | 15 | 3,489 | 4,992 | 2,995 |
| Diarrhoea | 12,458 | 14 | 3,448 | 5,812 | 2,525 |
| Maternal exposure during pregnancy | 12,351 | 14 | 2,579 | 3,284 | 2,410 |
| Confusional state | 12,240 | 14 | 3,250 | 6,842 | 3,096 |
| Malaise | 12,080 | 15 | 3,082 | 5,737 | 2,540 |
| Insomnia | 11,415 | 14 | 2,878 | 3,977 | 2,169 |